Data comes from a MSc thesis project and consists of 216 samples of granules in glass vials analysed by NIR. A downscaled dry granulation process was developed during the project and designed such that three quality attributes variances could be controlled:
- Model API concentration (Bovine Serum Albumin, BSA)
- Six levels ranging from 2% to 15% w/w
- Particle size
- Three levels, controlled by material mass used during compaction (1 g, 1.5 g and 2 g).
- Moisture content
- Four levels, controlled by the use of desiccators with relative humidity ranging from 11% to 62%.
Triplicates were produced of each attribute combination. Each sample was measured three times using a Bruker MPA II NIR equipment with resolution 8 cm-1, 64 scans and in the spectral range 11550 cm-1 to 3950 cm-1 for each measurement. The samples were measured before and after moisturization. Download the data here.